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HelpTest Code PBPFD Lead Profile Occupational Exposure, Blood
Ordering Guidance
This test is only for assessment of occupational exposure to lead. The preferred test for lead toxicity in children is blood lead. For more information see:
-PBDV / Lead, Venous, with Demographics, Blood
-PBDC / Lead, Capillary, with Demographics, Blood
The preferred screening test for suspicion of a hepatic porphyria is urine porphyrins. For more information see PQNRU / Porphyrins, Quantitative, Random, Urine.
Necessary Information
Include a list of medications the patient is currently taking.
Specimen Required
Both EDTA whole blood and heparin whole blood specimens are required.
Patient Preparation:
1. High concentrations of gadolinium and iodine are known to interfere with most inductively couple plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
2. Patient should abstain from alcohol for 24 hours prior to specimen collection.
Specimen Type: Whole blood
Supplies:
-Metal Free B-D Tube (EDTA), 6 mL (T183)
-Metal Free B-D Tube (EDTA), 3 mL (T989)
-Microtainer (EDTA) Tube, 0.5 mL (T174)
Container/Tube:
Preferred: Royal blue-top BD Vacutainer Plus with EDTA blood collection tube (6 mL) (BD catalog no. 368381)
Acceptable: Royal blue-top BD vacutainer with EDTA blood collection tube (3 mL), BD Microtainer with EDTA, or royal blue-top Monoject trace element blood collection tube
Specimen Volume: 2 mL
Collection Instructions:
1. See Metal Analysis Specimen Collection and Transport for complete instructions.
2. Send whole blood specimen in original tube. Do not aliquot.
3. Refrigerate specimen as soon as possible.
Specimen Type: Whole blood
Container/Tube:
Preferred: Green top (sodium heparin)
Acceptable: Dark blue top (metal free heparin), green top (lithium heparin), or lavender top (EDTA)
Specimen Volume: 4 mL
Collection Instructions: Refrigerate specimen as soon as possible after collection.
Forms
Useful For
Detecting lead toxicity due to occupational exposure
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| PBB | Lead, B | Yes, (order PBDV) | Yes |
| PPFE | Protoporphyrins, Fractionation, WB | Yes | Yes |
| DEMO5 | Patient Demographics | No | Yes |
Special Instructions
Method Name
PBB: Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
PPFE: High-Performance Liquid Chromatography (HPLC) with Fluorescence Detection
Reporting Name
Lead Profile Occ Exposure, BSpecimen Type
Whole bloodSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Refrigerated | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Clotted blood | Reject |
Reference Values
LEAD: <3.5 mcg/dL
The Occupational Safety and Health Administration (OSHA) recommended limit for blood lead level is 40 mcg/dL (OSHA 1978).
The biological exposure index (BEI) for Pb in blood of exposed workers is 20 mcg/dL (ACGIH 2018).
Critical Values:
Pediatrics (≤15 years): ≥20.0 mcg/dL
Adults (≥16 years): ≥70.0 mcg/dL
PROTOPORPHYRINS, FRACTIONATION
Free Protoporphyrin: <20 mcg/dL
Zinc-Complexed Protoporphyrin: <60 mcg/dL
Day(s) Performed
Monday, Wednesday, Friday
Report Available
2 to 6 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83655
82542
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PBPFD | Lead Profile Occ Exposure, B | 29588-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| VECP | Venous/Capillary | 31208-2 |
| 8602 | Lead, B | 77307-7 |
| 2327 | Zinc-Complexed Protoporphyrin | 2895-1 |
| 2326 | Free Protoporphyrin | 94491-8 |
| PTADD | Patient Street Address | 56799-0 |
| PTCIT | Patient City | 68997-6 |
| 29511 | Interpretation | 59462-2 |
| PTSTA | Patient State | 46499-0 |
| PTZIP | Patient Zip Code | 45401-7 |
| PTCNT | Patient County | 87721-7 |
| PTPHO | Patient Home Phone | 42077-8 |
| PTRAC | Patient Race | 32624-9 |
| PTETH | Patient Ethnicity | 69490-1 |
| PTOCC | Patient Occupation | 11341-5 |
| PTEMP | Patient Employer | 80427-8 |
| GDFN | Guardian First Name | 79183-0 |
| GDLN | Guardian Last Name | 79184-8 |
| MDORD | Health Care Provider Name | 52526-1 |
| MDADD | Health Care Provider Street Address | 74221-3 |
| MDCIT | Health Care Provider City | 52531-1 |
| MDSTA | Health Care Provider State | 52532-9 |
| MDZIP | Health Care Provider Zip Code | 87720-9 |
| MDPHO | Health Care Provider Phone | 68340-9 |
| LABPH | Submitting Laboratory Phone | 65651-2 |