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Test Code PBC2 SP100 and GP210 Antibodies, IgG, Serum


Additional Testing Requirements


This is a first line test when primary biliary cholangitis is strongly suspected. It should be ordered in conjunction with AMA / Mitochondrial Antibodies (M2), Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.0 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Evaluating the risk of primary biliary cholangitis in anti-mitochondrial antibody (AMA)-negative patients by identification of Sp100 and gp210 antibodies

 

Estimating risk in AMA-positive patients with incomplete feature of disease

Profile Information

Test ID Reporting Name Available Separately Always Performed
SP100 SP100 Antibody, IgG, S Yes Yes
GP210 GP210 Antibody, IgG, S Yes Yes

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

SP100 and GP210 Antibodies, IgG, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK
Heat-treated specimen Reject

Reference Values

Negative: ≤20.0 Units

Equivocal: 20.1-24.9 Units

Positive: ≥25.0 Units

Day(s) Performed

Tuesday

Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83516 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PBC2 SP100 and GP210 Antibodies, IgG, S 106055-7

 

Result ID Test Result Name Result LOINC Value
SP100 SP100 Antibody, IgG, S 96565-7
GP210 GP210 Antibody, IgG, S 96560-8

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request (T728) with the specimen.

Testing Algorithm

For more information see First-Line Screening for Autoimmune Liver Disease Algorithm.