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Test Code NSESF Neuron-Specific Enolase (NSE), Spinal Fluid

Reporting Name

Neuron Specific Enolase, CSF

Useful For

An auxiliary test in the diagnosis of Creutzfeldt-Jakob disease

 

An auxiliary test in the diagnosis of small cell lung carcinoma metastasis to central nervous system or leptomeninges

Method Name

Homogeneous Time-Resolved Fluorescence

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

CSF


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 15 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus Reject

Reference Values

Normal: ≤15 ng/mL

Indeterminate: 15-30 ng/mL

Elevated: >30 ng/mL

Elevated results may indicate the need for additional workup. Possible causes may be neuron-specific enolase-secreting central nervous system/leptomeningeal tumor or rapid neuronal destruction from a variety of causes. In the context of dementia, elevated results may be suggestive of Creutzfeldt-Jakob disease.

Day(s) Performed

Monday through Saturday

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NSESF Neuron Specific Enolase, CSF 44802-7

 

Result ID Test Result Name Result LOINC Value
NSESF Neuron Specific Enolase, CSF 44802-7

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Report Available

1 to 3 days