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Test Code GFATS Glial Fibrillary Acidic Protein Alpha Subunit Antibody, Immunofluorescence Titer Assay, Serum


Necessary Information


Provide the following information:

-Relevant clinical information

-Ordering provider name, phone number, mailing address, and e-mail address



Specimen Required


Only orderable as a reflex. For more information see:  

ENS2 / Encephalopathy, Autoimmune Evaluation Serum 

DMS2 / Dementia, Autoimmune Evaluation, Serum 

EPS2 / Epilepsy, Autoimmune Evaluation, Serum 

MAS1 / Autoimmune Myelopathy Evaluation, Serum


Useful For

Reporting an end titer result in serum specimens

 

Distinguishing autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy from infectious meningoencephalitis and idiopathic inflammatory central nervous system (CNS) disorders such as multiple sclerosis, vasculitis and sarcoidosis, disorders commonly considered in the differential diagnosis

 

Alerting the clinician that the patient has an immune-mediated, steroid-responsive disorder and to search for a malignancy

Testing Algorithm

If immunofluorescence assay (IFA) pattern suggests GFAP, then GFAP IFA titer and GFAP cell-binding assay (CBA) are performed at an additional charge.

Method Name

Only orderable as a reflex. For more information see:

ENS2 / Encephalopathy, Autoimmune Evaluation Serum

DMS2 / Dementia, Autoimmune Evaluation, Serum

EPS2 / Epilepsy, Autoimmune Evaluation, Serum

MAS1 / Autoimmune Myelopathy Evaluation, Serum

 

Indirect Immunofluorescence Assay (IFA)

Reporting Name

GFAP IFA Titer, S

Specimen Type

Serum

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Only orderable as a reflex. For more information see:

ENS2 / Encephalopathy, Autoimmune Evaluation Serum

DMS2 / Dementia, Autoimmune Evaluation, Serum

EPS2 / Epilepsy, Autoimmune Evaluation, Serum

MAS1 / Autoimmune Myelopathy Evaluation, Serum

 

<1:240

Day(s) Performed

Monday through Sunday

Report Available

10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86256

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GFATS GFAP IFA Titer, S 93423-2

 

Result ID Test Result Name Result LOINC Value
605133 GFAP IFA Titer, S 93423-2