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HelpTest Code E1 Estrone, Serum
Reporting Name
Estrone, SUseful For
As part of the diagnosis and workup of precocious and delayed puberty in females and, to a lesser degree, males
As part of the diagnosis and workup of suspected disorders of sex steroid metabolism (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)
As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
Monitoring low-dose female hormone replacement therapy in postmenopausal women
Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)
Testing Algorithm
For information see Steroid Pathways.
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.2 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: For more information see Steroid Pathways.
Specimen Minimum Volume
0.7 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Special Instructions
Reference Values
CHILDREN*
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-16 pg/mL |
|
Stage II |
11.5 years |
Undetectable-22 pg/mL |
|
Stage III |
13.6 years |
10-25 pg/mL |
|
Stage IV |
15.1 years |
10-46 pg/mL |
|
Stage V |
18 years |
10-60 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (± 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-29 pg/mL |
|
Stage II |
10.5 years |
10-33 pg/mL |
|
Stage III |
11.6 years |
15-43 pg/mL |
|
Stage IV |
12.3 years |
16-77 pg/mL |
|
Stage V |
14.5 years |
17-200 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (± 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) Performed
Monday through Saturday
CPT Code Information
82679
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| E1 | Estrone, S | 2258-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81418 | Estrone, S | 2258-2 |