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Test Code DRVI3 Dilute Russell's Viper Venom Time (DRVVT) Confirmation Ratio, Plasma


Ordering Guidance


Because no single coagulation test can identify or exclude all lupus anticoagulants (LA), and because of the complexity of testing LA, one of the following Coagulation Consultation reflexive panel procedures are recommended if clinically indicated:

ALUPP / Lupus Anticoagulant Profile, Plasma

AATHR / Thrombophilia Profile, Plasma and Whole Blood

APROL / Prolonged Clot Time Profile, Plasma



Additional Testing Requirements


Serum anticardiolipin antibody testing (CLPMG / Phospholipid [Cardiolipin] Antibodies, IgG and IgM, Serum) and anti-beta-2 glycoprotein I (B2GMG / Beta-2 Glycoprotein 1 Antibodies, IgG and IgM, Serum) antibody testing should also be performed in conjunction with coagulation-based testing for lupus anticoagulants to enhance detection of different types of antiphospholipid antibodies.



Specimen Required


Only orderable as part of a reflex. For more information see DRVI1 / Dilute Russell's Viper Venom Time (DRVVT), with Reflex, Plasma.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing.

2. Centrifuge, remove plasma, and centrifuge plasma again.

3. Aliquot into a separate plastic vial, leaving 0.25 mL in the bottom of the centrifuged vial.

4. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, -40° C or below.


Useful For

Confirming the presence or helping to exclude the presence of lupus anticoagulants (LA)

 

Identifying LA that do not prolong the activated partial thromboplastin time (APTT)

 

Evaluating unexplained prolongation of the APTT or prothrombin time clotting tests

 

Distinguishing LA from a specific coagulation factor inhibitor or coagulation factor deficiencies

Method Name

Only orderable as part of a reflex. For more information see DRVI1 / Dilute Russell's Viper Venom Time (DRVVT), with Reflex, Plasma.

 

Optical Clot-Based

Reporting Name

DRVVT Confirmation Ratio

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Only orderable as part of a reflex. For more information see DRVI1 / Dilute Russell's Viper Venom Time (DRVVT), with Reflex, Plasma.

 

<1.20

Normal ranges for children: not clearly established, but similar to normal ranges for adults, except for newborn infants whose results may not reach adult values until 3 to 6 months.

Day(s) Performed

Monday through Friday

Report Available

2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85613

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DRVI3 DRVVT Confirmation Ratio 50410-0

 

Result ID Test Result Name Result LOINC Value
RCRI3 DRVVT Confirmation Ratio 50410-0

Specimen Minimum Volume

0.5 mL