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Test Code CLOBZ Clobazam and Metabolite, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Collect blood immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.

Additional Information: Trough specimens are recommended as therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose).


Useful For

Monitoring clobazam therapy

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Clobazam and metabolite, S

Specimen Type

Serum Red

Specimen Minimum Volume

0.35 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Clobazam

Therapeutic Range: 30-300 ng/mL

 

N-desmethylclobazam (Norclobazam)

Therapeutic Range: 300-3,000 ng/mL

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80339 (G0480 if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CLOBZ Clobazam and metabolite, S 79408-1

 

Result ID Test Result Name Result LOINC Value
65483 Clobazam 3487-6
92363 N-desmethylclobazam 35107-2

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.